A
number of things can cause excessive hair loss. For example, about 3 or
4 months after an illness or a major surgery, you may suddenly lose a
large amount of hair. This hair loss is related to the stress of the
illness and is temporary.

Hormonal problems may cause hair
loss. If your thyroid gland is overactive or underactive, your hair may
fall out. This hair loss usually can be helped by treatment thyroid
disease. Hair loss may occur if male or female hormones, known as
androgens and estrogens, are out of balance. Correcting the hormone
imbalance may stop your hair loss.

Many women notice hair loss
about 3 months after they’ve had a baby. This loss is also related to
hormones. During pregnancy, high levels of certain hormones cause the
body to keep hair that would normally fall out. When the hormones
return to pre-pregnancy levels, that hair falls out and the normal
cycle of growth and loss starts again.

Some medicines can
cause hair loss. This type of hair loss improves when you stop taking
the medicine. Medicines that can cause hair loss include blood thinners
(also called anticoagulants), medicines used for gout, medicines used
in chemotherapy to treat cancer, vitamin A (if too much is taken),
birth control pills and antidepressants.

Certain infections can
cause hair loss. Fungal infections of the scalp can cause hair loss in
children. The infection is easily treated with antifungal medicines.

Finally,
hair loss may occur as part of an underlying disease, such as lupus or
diabetes. Since hair loss may be an early sign of a disease, it is
important to find the cause so that it can be treated.

Depending
on your type of hair loss, treatments are available. If a medicine is
causing your hair loss, your doctor may be able to prescribe a
different medicine. Recognizing and treating an infection may help stop
the hair loss. Correcting a hormone imbalance may prevent further hair
loss.

Medicines may also help slow or prevent the development of
common baldness. One medicine, finasteride (brand name: Propecia), It comes in pills and is
only for men. It may take up to 6 months before you can tell if it works for you so don’t you quit ,time is the key.

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Propecia is for use by MEN ONLY.
Please read this leaflet before you start taking PROPECIA. Also, read the information included with
PROPECIA each time you renew your prescription, just in case anything has changed. Remember, this
leaflet does not take the place of careful discussions with your doctor. You and your doctor should discuss
PROPECIA when you start taking your medication and at regular checkups.
What is PROPECIA used for?
PROPECIA is used for the treatment of male pattern hair loss on the vertex and the anterior mid-scalp
area.
PROPECIA is for use by MEN ONLY and should NOT be used by women or children.
What is male pattern hair loss?
Male pattern hair loss is a common condition in which men experience thinning of the hair on the scalp.
Often, this results in a receding hairline and/or balding on the top of the head. These changes typically
begin gradually in men in their 20s.
Doctors believe male pattern hair loss is due to heredity and is dependent on hormonal effects. Doctors
refer to this type of hair loss as androgenetic alopecia.
Results of clinical studies:
For 12 months, doctors studied over 1800 men aged 18 to 41 with mild to moderate amounts of ongoing
hair loss. Of these men, approximately 1200 with hair loss at the top of the head participated in additional
extension studies, resulting in a total study time of up to five years. In general, men who took PROPECIA
maintained or increased the number of visible scalp hairs and noticed improvement in their hair in the first
year. Improvement, compared to the start of the study, was maintained through the remaining years of
treatment. Hair counts in men who did not take PROPECIA continued to decrease.
In one study, patients were questioned on the growth of body hair. PROPECIA did not appear to affect hair
in places other than the scalp.
Will PROPECIA work for me?
For most men, PROPECIA increases the number of scalp hairs in the first year of treatment, helping to fill
in thin or balding areas of the scalp. In addition, men taking PROPECIA may note a slowing of hair loss.
Although results will vary, generally you will not be able to grow back all of the hair you have lost. There is
not sufficient evidence that PROPECIA works in the treatment of receding hairline in the temporal area on
both sides of the head.
Male pattern hair loss occurs gradually over time. On average, healthy hair grows only about half an inch
each month. Therefore, it will take time to see any effect.

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PROPECIA
(finasteride)
Tablets, 1 mg
DESCRIPTION
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(Finasteride), a synthetic 4-azasteroid compound, is a specific inhibitor of steroid Type II
5α-reductase, an intracellular
enzyme that converts
the androgen testosterone into
5α-dihydrotestosterone (DHT).
Finasteride
is
4-azaandrost-1-ene-17-carboxamide,N-(1,1-dimethylethyl)-3-oxo-,(5α,17β)-.
The
empirical formula of finasteride is C23H34N2O3
and its molecular weight is 372.55. Its structural formula is:
Finasteride is a white crystalline powder with a melting point near 250°C. It is freely soluble in
chloroform and in lower alcohol solvents but is practically insoluble in water.
PROPECIA tablets for oral administration are film-coated tablets that contain 1 mg of finasteride and
the following inactive ingredients: lactose monohydrate, microcrystalline cellulose, pregelatinized starch,
sodium starch glycolate, hydroxypropyl methylcellulose, hydroxypropyl cellulose LF, titanium dioxide,
magnesium stearate, talc, docusate sodium, yellow ferric oxide, and red ferric oxide.
CLINICAL PHARMACOLOGY(BUY PROPECIA)
Finasteride is a competitive and specific inhibitor of Type II 5α-reductase, an intracellular enzyme that
converts the androgen testosterone into DHT. Two distinct isozymes are found in mice, rats, monkeys,
and humans: Type I and II. Each of these isozymes is differentially expressed in tissues and
developmental stages. In humans, Type I 5α-reductase is predominant in the sebaceous glands of most
regions of skin, including scalp, and liver. Type I 5α-reductase is responsible for approximately one-third
of circulating DHT. The Type II 5α-reductase isozyme is primarily found in prostate, seminal vesicles,
epididymides, and hair follicles as well as liver, and is responsible for two-thirds of circulating DHT.
In humans, the mechanism of action of finasteride is based on its preferential inhibition of the Type II
isozyme. Using native tissues (scalp and prostate), in vitro binding studies examining the potential of
finasteride to inhibit either isozyme revealed a 100-fold selectivity for the human Type II 5α-reductase over
Type I isozyme (IC
50
=500 and 4.2 nM for Type I and II, respectively). For both isozymes, the inhibition by
finasteride is accompanied by reduction of the inhibitor to dihydrofinasteride and adduct formation with
NADP+. The turnover for the enzyme complex is slow (t
1/2
approximately 30 days for the Type II enzyme
complex and 14 days for the Type I complex).
Finasteride has no affinity for the androgen receptor and has no androgenic, antiandrogenic,
estrogenic, antiestrogenic, or progestational effects. Inhibition of Type II 5α-reductase blocks the
peripheral conversion of testosterone to DHT, resulting in significant decreases in serum and tissue DHT
concentrations. Finasteride produces a rapid reduction in serum DHT concentration, reaching 65%.

This sheet talks about the risks that exposure to finasteride can have during pregnancy. With each pregnancy, all
women have a 3% to 5% chance of having a baby with a birth defect. This information should not take the place
of medical care and advice from your health care provider.

What is finasteride?
Finasteride is a medication used for the
treatment and prevention of male pattern
baldness. It inhibits a chemical in the body
called 5-alpha-reductase. Finasteride has also
been approved for treatment of benign prostatic
hyperplasia. Finasteride is not approved at this
time for use in women. Finasteride is marketed
under the brand names Propecia
and Proscar.

My partner is taking finasteride but is

wondering if he should stop before I become

pregnant. Is this necessary and if so, how long

does it stay in the body?
The benefits of taking the medication
and any possible adverse outcomes from not
taking it should be taken into account and
discussed with his healthcare provider before
deciding to stop treatment. There is no known
reason for him to stop taking this medication
while planning a family. If he does decide to
stop using finasteride, it takes on average two
days for most of the drug to be eliminated from
the body after the last dose.

If my partner decides to continue taking

finasteride, will it be more difficult for me to

become pregnant?
There is no evidence to say that if your
partner is taking this medication it will make it
more difficult for you to become pregnant.
Animal studies suggest a temporary decrease in
male fertility, however no adverse effect has
been found in semen in humans. There are no
reports linking this medication to human
infertility or an inability to become pregnant.

Is there an increased risk for birth defects if

the baby’s father is taking finasteride when I

become pregnant?
Studies
in animals
found that
pregnancies sired by male rats that were given
large doses of finasteride did not result in
babies born with birth defects. There are no
such studies in humans at this time.

Should my partner stop taking finasteride

while I am pregnant?
There is a theoretical, although highly
unlikely, risk for birth defects of a male fetus’s
sex organs if the couple has intercourse during
the stage of pregnancy when the sex organs are
developing (8 to 15 weeks of gestation).
However, the amount of the drug found in the
semen is very small and is not felt to be enough
to harm a male baby.

If my partner stops using finasteride will there

be side effects?
Finasteride must be used daily for three
months, on average, before results can be seen.
Continued use is recommended to sustain this
benefit. There is no lasting benefit if treatment
is stopped, and there will be a reversal of any
benefits within twelve months of stopping
treatment.
If I touch or handle finasteride tablets during
pregnancy does the baby have an increased
risk for birth defects?
Animal studies have shown that
pregnant monkeys who were given large doses
of finasteride orally had male offspring with
abnormalities of the sex organs. There are no
human studies. Based on this information,
women are told not to handle tablets that are
crushed or broken during pregnancy. However,
it is highly unlikely that enough of the
medication would be absorbed through
unbroken skin during the course of normal
handling to be a problem.

Can I take finasteride while breastfeeding?
This medication has not been approved
for use by women. Even if a woman does
decide to use finasteride and breastfeed, there
are no studies to show if it is excreted in breast
milk.

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